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WEST WOLF MEDICINALS

Research Documentation

At West Wolf Medicinals, we’re not about pseudoscience and partial truths. Trends are not our thing. Health is simply too important. So, when we set out to create our blends, we wanted to create products with the greatest potency, highest quality, and backed by science. The results are everything we think a health supplement should be. To learn more about the specific healing qualities of our mushrooms, as well as the herbs in our blends, and why we paired them, please refer to the studies listed below.

Studies on the Herbs We Use

Chase Your Stars Anti-Aging Formula

https://www.healthline.com/health/food-nutrition/marshmallow-root

https://www.healthline.com/nutrition/10-proven-benefits-of-cinnamon#TOC_TITLE_HDR_8

https://pubmed.ncbi.nlm.nih.gov/24349472/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665023/

https://www.verywellhealth.com/holy-basil-4766587

https://health.clevelandclinic.org/turmeric-health-benefits/

Love & Desire Sexual Energizer

https://www.healthline.com/nutrition/12-proven-ashwagandha-benefits

https://pubmed.ncbi.nlm.nih.gov/24349472/

https://www.healthline.com/nutrition/rosehip-tea

https://www.healthline.com/nutrition/10-proven-benefits-of-cinnamon#TOC_TITLE_HDR_8

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665023/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657287/

https://www.medicalnewstoday.com/articles/322511

https://www.healthshots.com/healthy-eating/nutrition/7-health-benefits-of-nettle-tea-and-how-to-make-it/

Ashwagandha’s Effect on Resistance to Fatigue and Stress
Clinical trial exploring the impact of Ashwagandha on chronically stressed humans.

Ashwagandha’s Impact on Mental Stamina
A study exploring the impact of Ashwagandha on cognitive and psychomotor performance.

Ashwagandha’s Role in Supporting Healthy Joints
A paper reviewing the properties that Ashwagandha has for improving joint pain and stiffness.

Ashwagandha and a Healthy Response to Stress
A study exploring the impact of Ashwagandha on stress and inflammation in the body.

Anti-inflammatory Properties Turmeric
A scientific study on turmeric, it’s chemical composition and how it impacts inflammation in the human body.

Life Force Overall Well-Being

This product doesn’t contain herbs. See below to learn more about the specific mushrooms we use.

Specific Mushrooms in our Blends

Benefits of Lion's Mane

1. “Nerve Growth Factor-Inducing Activity Of Hericium Erinaceus In 1321N1 Human Astrocytoma Cells”. Biological & Pharmaceutical Bulletin 31 (9).

2. “Effects Of Amycenone On Serum Levels Of Tumor Necrosis Factor-Α, Interleukin-10, And Depression-Like Behavior In Mice After Lipopolysaccharide Administration”. Pharmacology Biochemistry And Behavior 136: 7-12.

3. “Erinacine A-Enriched Hericium Erinaceus Mycelium Produces Antidepressant-Like Effects Through Modulating BDNF/PI3K/Akt/GSK-3Β Signaling In Mice”. International Journal Of Molecular Sciences 19.

4. “Immunomodulatory Effects Of Hericium Erinaceus Derived Polysaccharides Are Mediated By Intestinal Immunology”. Food & Function 8.

5. “Immunomodulatory Activities Of A Fungal Protein Extracted From Hericium Erinaceus Through Regulating The Gut Microbiota”. Frontiers In Immunology 8.

6 Effects of Beta Glucans on the Immune System

Additional Scientific Studies & Clinical Trials of the Effectiveness of Lion’s Mane and BetaGlucans

  1. Lai, Puei-Lene, Murali Naidu, Vikineswary Sabaratnam, Kah-Hui Wong, Rosie Pamela David, Umah Rani Kuppusamy, Noorlidah Abdullah, and Sri Nurestri A. Malek. 2013. “Neurotrophic Properties Of The Lion’s Mane Medicinal Mushroom, Hericium Erinaceus (Higher Basidiomycetes) From Malaysia”. International Journal Of Medicinal Mushrooms 15 (6): 539-554. Begell House. doi:10.1615/intjmedmushr.v15.i6.30.
  2. Mori, K. et al. (2011) “Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice”, Biomedical Research, 32(1), pp. 67-72. doi: 10.2220/biomedres.32.67.

Benefits of Shiitake

1. “Characterization Of Vitamin B12 Compounds In The Fruiting Bodies Of Shiitake Mushroom (Lentinula Edodes) And Bed Logs After Fruiting Of The Mushroom”. Mycoscience 55.

2. “The Pharmacological Potential Of Mushrooms”. Evidence-Based Complementary And Alternative Medicine.

3.“Recent Progress Of Research On Medicinal Mushrooms, Foods, And Other Herbal Products Used In Traditional Chinese Medicine”. Journal Of Traditional And Complementary Medicine.

4. “Consuminglentinula Edodes(Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention In Healthy Young Adults”. Journal Of The American College Of Nutrition.

5. Immune Enhancing Effects from Shiitake

6.Dai, Xiaoshuang, Joy M. Stanilka, Cheryl A. Rowe, Elizabethe A. Esteves, Carmelo Nieves, Samuel J. Spaiser, Mary C. Christman, Bobbi Langkamp-Henken, and Susan S. Percival. 2015. “Consuminglentinula Edodes(Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention In Healthy Young Adults”. Journal Of The American College Of Nutrition 34 (6): 478-487. doi:10.1080/07315724.2014.950391.

7.Handayani, D., J. Chen, B. J. Meyer, and X. F. Huang. 2011. “Dietary Shiitake Mushroom (Lentinus Edodes) Prevents Fat Deposition And Lowers Triglyceride In Rats Fed A High-Fat Diet”. Journal Of Obesity 2011: 1-8. doi:10.1155/2011/258051.

8.Bito, Tomohiro, Fei Teng, Noriharu Ohishi, Shigeo Takenaka, Emi Miyamoto, Emi Sakuno, Kazuhisa Terashima, Yukinori Yabuta, and Fumio Watanabe. 2014. “Characterization Of Vitamin B12 Compounds In The Fruiting Bodies Of Shiitake Mushroom (Lentinula Edodes) And Bed Logs After Fruiting Of The Mushroom”. Mycoscience 55 (6): 462-468. doi:10.1016/j.myc.2014.01.008.

 

Benefits of Reishi

  1. “Spore Powder Ofganoderma Lucidum Improves Cancer-Related Fatigue In Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial”. Evidence-Based Complementary And Alternative Medicine 2012.

2. “A Randomized, Double-Blind And Placebo-Controlled Study Of Aganoderma Lucidumpolysaccharide Extract In Neurasthenia”. Journal of Medicinal Food. 

3. “Neuroprotective Effects Of Ganoderma Lucidum Polysaccharides Against Oxidative Stress-Induced Neuronal Apoptosis”. Neural Regeneration Research.

4. Cellular And Molecular Mechanisms Of Immuno-Modulation By Ganoderma Lucidum”. Journal Of Pharmacological Sciences.

5. The mushroom Ganoderma lucidum (G. lucidum) possesses potential anticancer activity.

6. “Natural Killer Cells: In Health And Disease”. Hematology/Oncology And Stem Cell Therapy.

7.  Reishi as an Anti-Cancer Agent

8.Gao, Yihuai, Shufeng Zhou, Wenqi Jiang, Min Huang, and Xihu Dai. 2003. “Effects Of Ganopoly®(Aganoderma Lucidumpolysaccharide Extract) On The Immune Functions In Advanced‐Stage Cancer Patients”. Immunological Investigations 32 (3): 201-215. doi:10.1081/imm-120022979.

9.Socala, K. et al. (2015) “Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice”, International Journal of Medicinal Mushrooms, 17(3), pp. 209-218. doi: 10.1615/intjmedmushrooms.v17.i3.10.

Benefits of Chaga

1. “Immunomodulatory Activity Of The Water Extract From Medicinal Mushroominonotus Obliquus”. Mycobiology 3.

2. Memorial Sloan Kettering Cancer Center on Benefits of Chaga

Benefits of Turkey Tail

1. https://pubmed.ncbi.nlm.nih.gov/7910230/

2. https://pubmed.ncbi.nlm.nih.gov/12470440/

3. https://www.hindawi.com/journals/isrn/2012/251632/

Benefits of Cordyceps

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909570/

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174424/

3. https://www.liebertpub.com/doi/abs/10.1089/acm.2009.0226

Additional Studies of the Benefits of Medicinal Mushrooms

  1. Aung, Steven Kh. 2005. “The Clinical Use Of Mushrooms From A Traditional Chinese Medical Perspective”. International Journal Of Medicinal Mushrooms, 375-376. doi:10.1615/intjmedmushrooms.v7.i3.290
  2. D, Akramiene, Kondrotas A, Didziapetriene J, and Kevelaitis E. 2007. “Effects Of Beta-glucans On The Immune System”. Medicina (Kaunas, Lithuania) 43 (8). https://pubmed.ncbi.nlm.nih.gov/17895634/.
  3. HONG, HEEOK, CHANG-JU KIM, JAE-DEUNG KIM, and JIN-HEE SEO. 2014. “Β-Glucan Reduces Exercise-Induced Stress Through Downregulation Of C-Fos And C-Jun Expression In The Brains Of Exhausted Rats”. Molecular Medicine Reports 9 (5): 1660-1666. doi:10.3892/mmr.2014.2005.
  4. Sabaratnam, Vikineswary, Wong Kah-Hui, Murali Naidu, and Pamela Rosie David. 2013. “Neuronal Health – Can Culinary And Medicinal Mushrooms Help?”. Journal Of Traditional And Complementary Medicine 3 (1): 62-68. doi:10.4103/2225-4110.106549.
  5. Lai, P. et al. (2013) “Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia”, International Journal of Medicinal Mushrooms, 15(6), pp. 539-554. doi: 10.1615/intjmedmushr.v15.i6.30.
  6. Elsayed, E. et al. (2014) “Mushrooms: A Potential Natural Source of Anti-Inflammatory Compounds for Medical Applications”, Mediators of Inflammation, 2014, pp. 1-15. doi: 10.1155/2014/805841.
  7. Vitak, T. et al. (2017) “Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus”, World Journal of Diabetes, 8(5), p. 187. doi: 10.4239/wjd.v8.i5.187.
  8. Wong, K. et al. (2011) “Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)”, Evidence-Based Complementary and Alternative Medicine, 2011, pp. 1-10. doi: 10.1093/ecam/neq062.
  9. Geng, P. et al. (2017) “Anti-fatigue Functions and Mechanisms of Edible and Medicinal Mushrooms”, BioMed Research International, 2017, pp. 1-16. doi: 10.1155/2017/9648496.
  10. Mori, Koichiro, Yutaro Obara, Mitsuru Hirota, Yoshihito Azumi, Satomi Kinugasa, Satoshi Inatomi, and Norimichi Nakahata. 2008. “Nerve Growth Factor-Inducing Activity Of Hericium Erinaceus In 1321N1 Human Astrocytoma Cells”. Biological & Pharmaceutical Bulletin 31 (9): 1727-1732. doi:10.1248/bpb.31.1727.
  11. Yao, Wei, Ji-chun Zhang, Chao Dong, Cun Zhuang, Susumu Hirota, Kazutoyo Inanaga, and Kenji Hashimoto. 2015. “Effects Of Amycenone On Serum Levels Of Tumor Necrosis Factor-Α, Interleukin-10, And Depression-Like Behavior In Mice After Lipopolysaccharide Administration”. Pharmacology Biochemistry And Behavior 136: 7-12. doi:10.1016/j.pbb.2015.06.012.
  12. Chiu, Chun-Hung, Charng-Cherng Chyau, Chin-Chu Chen, Li-Ya Lee, Wan-Ping Chen, Jia-Ling Liu, Wen-Hsin Lin, and Mei-Chin Mong. 2018. “Erinacine A-Enriched Hericium Erinaceus Mycelium Produces Antidepressant-Like Effects Through Modulating BDNF/PI3K/Akt/GSK-3Β Signaling In Mice”. International Journal Of Molecular Sciences 19 (2): 341. doi:10.3390/ijms19020341.
  13. Sheng, Xiaotong, Jingmin Yan, Yue Meng, Yuying Kang, Zhen Han, Guihua Tai, Yifa Zhou, and Hairong Cheng. 2017. “Immunomodulatory Effects Of Hericium Erinaceus Derived Polysaccharides Are Mediated By Intestinal Immunology”. Food & Function 8 (3): 1020-1027. doi:10.1039/c7fo00071e.
  14. Diling, Chen, Zheng Chaoqun, Yang Jian, Li Jian, Su Jiyan, Xie Yizhen, and Lai Guoxiao. 2017. “Immunomodulatory Activities Of A Fungal Protein Extracted From Hericium Erinaceus Through Regulating The Gut Microbiota”. Frontiers In Immunology 8. doi:10.3389/fimmu.2017.00666.
  15. Kim, Yeon-Ran. 2005. “Immunomodulatory Activity Of The Water Extract From Medicinal Mushroominonotus Obliquus”. Mycobiology 33 (3): 158. doi:10.4489/myco.2005.33.3.158.
  16. Geng, Ping, Ka-Chai Siu, Zhaomei Wang, and Jian-Yong Wu. 2017. “Antifatigue Functions And Mechanisms Of Edible And Medicinal Mushrooms”. Biomed Research International 2017: 1-16. doi:10.1155/2017/9648496.
  17. “Maitake”. 2020. Memorial Sloan Kettering Cancer Center. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/maitake#references-2.
  18. Vaclav Vetvicka, Jana Vetvickova. 2014. “Immune-Enhancing Effects Of Maitake (Grifola Frondosa) And Shiitake (Lentinula Edodes) Extracts”. Annals Of Translational Medicine 2 (2). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202470/
  19. Zhao, Hong, Qingyuan Zhang, Ling Zhao, Xu Huang, Jincai Wang, and Xinmei Kang. 2012. “Spore Powder Ofganoderma Lucidumimproves Cancer-Related Fatigue In Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial”. Evidence-Based Complementary And Alternative Medicine 2012: 1-8. doi:10.1155/2012/809614.
  20. Tang, Wenbo, Yihuai Gao, Guoliang Chen, He Gao, Xihu Dai, Jinxian Ye, Eli Chan, Min Huang, and Shufeng Zhou. 2005. “A Randomized, Double-Blind And Placebo-Controlled Study Of Aganoderma Lucidumpolysaccharide Extract In Neurasthenia”. Journal Of Medicinal Food 8 (1): 53-58. doi:10.1089/jmf.2005.8.53.
  21. Guo, Li-mei, Xin-zhi Sun, Ying Liao, and Wei Li. 2017. “Neuroprotective Effects Of Ganoderma Lucidum Polysaccharides Against Oxidative Stress-Induced Neuronal Apoptosis”. Neural Regeneration Research 12 (6): 953. doi:10.4103/1673-5374.208590.
  22. Lin, Zhi-Bin. 2005. “Cellular And Molecular Mechanisms Of Immuno-Modulation By Ganoderma Lucidum”. Journal Of Pharmacological Sciences 99 (2): 144-153. doi:10.1254/jphs.crj05008x.
  23. Mandal, Arundhati, and Chandra Viswanathan. 2015. “Natural Killer Cells: In Health And Disease”. Hematology/Oncology And Stem Cell Therapy 8 (2): 47-55. doi:10.1016/j.hemonc.2014.11.006.
  24. Bak, Won Chull, Ji Heon Park, Young Ae Park, and Kang Hyeon Ka. 2014. “Determination Of Glucan Contents In The Fruiting Bodies And Mycelia Of Lentinula Edodes Cultivars”. Mycobiology 42 (3): 301-304. doi:10.5941/myco.2014.42.3.301.
  25. Nitschke, Jörg, Hendrik Modick, Ekkehard Busch, Reimund Wantoch von Rekowski, Hans-Josef Altenbach, and Helga Mölleken. 2011. “A New Colorimetric Method To Quantify Β-1,3-1,6-Glucans In Comparison With Total Β-1,3-Glucans In Edible Mushrooms”. Food Chemistry 127 (2): 791-796. doi:10.1016/j.foodchem.2010.12.149.
  26. Lindequist, Ulrike, Timo H. J. Niedermeyer, and Wolf-Dieter Jülich. 2005. “The Pharmacological Potential Of Mushrooms”. Evidence-Based Complementary And Alternative Medicine 2 (3): 285-299. doi:10.1093/ecam/neh107.
  27. Lee, Kuo-Hsiung, Susan L. Morris-Natschke, Xiaoming Yang, Rong Huang, Ting Zhou, Shou-Fang Wu, Qian Shi, and Hideji Itokawa. 2012. “Recent Progress Of Research On Medicinal Mushrooms, Foods, And Other Herbal Products Used In Traditional Chinese Medicine”. Journal Of Traditional And Complementary Medicine 2 (2): 1-12. doi:10.1016/s2225-4110(16)30081-5.